Treatment of Psoriasis With Topically Applied Tretinoin and Steroid Ointment
- 1 August 1975
- journal article
- clinical trial
- Published by American Medical Association (AMA) in Archives of Dermatology
- Vol. 111 (8) , 1001-1003
- https://doi.org/10.1001/archderm.1975.01630200061006
Abstract
The sequential application of tretinoin and a corticosteroid ointment was considerably more effective in the treatment of plaque-type psoriasis than either drug alone in a pilot study. The best results were obtained with 0.3% tretinoin followed by a potent corticosteroid ointment. Combined therapy was particularly efficacious in steroid-resistant psoriasis, including that on the palms, elbows, and knees. Irritancy from the high-strength tretinoin was a potentially troublesome sideeffect. Care must be taken to avoid drug contact on areas that are easily irritated.Keywords
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