Activated c-K-ras and c-N-ras oncogenes in 3-methylcholanthrene-induced BALB/c fibrosarcomas
- 1 August 1988
- journal article
- research article
- Published by Oxford University Press (OUP) in Carcinogenesis: Integrative Cancer Research
- Vol. 9 (8) , 1517-1519
- https://doi.org/10.1093/carcin/9.8.1517
Abstract
DNAs from fourteen fibrosarcomas induced by 3-methyl-cholanthrene (MCA) in BALB/c mice were analyzed for the presence of transforming oncogenes following transfection on NIH3T3 cells. Six transfection-positive DNAs contained an activated ras gene: four c-K- ras and two c-N- ras . These results demonstrate that c-K- ras is not the only oncogene of the ras family activated in MCA-induced murine fibrosarcomas as was previously indicated.This publication has 16 references indexed in Scilit:
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