Genetic models for CNS inflammation
- 1 February 2001
- journal article
- review article
- Published by Springer Nature in Nature Medicine
- Vol. 7 (2) , 161-166
- https://doi.org/10.1038/84603
Abstract
The use of transgenic technology to over-express or prevent expression of genes encoding molecules related to inflammation has allowed direct examination of their role in experimental disease. This article reviews transgenic and knockout models of CNS demyelinating disease, focusing primarily on the autoimmune disease multiple sclerosis, as well as conditions in which an inflammatory response makes a secondary contribution to tissue injury or repair, such as neurodegeneration, ischemia and trauma.Keywords
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