BEHAVIORAL EVIDENCE FOR STIMULATION OF CNS SEROTONIN RECEPTORS BY HIGH DOSES OF LSD

  • 1 January 1976
    • journal article
    • research article
    • Vol. 2  (2) , 149-164
Abstract
Systemic administration of LSD to rats induces a behavioral syndrome consisting of tremor, rigidity, Straub tail, hindlimb abduction, lateral head weaving and reciprocal forepaw treading. This syndrome is a reflection of increased activation of central serotonin receptors. Utilizing this behavioral measure, a marked supersensitivity to LSD was observed in rats whose serotonin nerve terminals were selectively destroyed, and a dramatic tolerance to LSD was observed following its repeated administration to normal rats. LSD can apparently stimulate CNS serotonin receptors to a degree which markedly affects behavior.

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