1,4-Oligoglucosides Inhibit the Binding of Aspergillus fumigatus Conidia to Human Monocytes

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Abstract
The binding of Aspergillus fumigatus conidia to human monocytes is mediated by a barley β-glucan-inhibitable receptor. The simplest linkages in this glucan are present in the disaccharides laminaribiose (β1,3) and cellobiose (β1,4). Although laminaribiose gave strong inhibition of conidial binding to monocytes, cellobiose and oligosaccharides with β1,4-linked glucose residues were more potent as specific inhibitors of this binding over similar concentrations. Increasing the number of β1,4-linked glucose residues led to greater inhibition of conidial binding by human monocytes.

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