RELATIONSHIP BETWEEN DOSE AND RESPONSE IN POSTHISTAMINIC PLASMA PEPSINOGEN IN DOGS

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Abstract
The effect of various doses of histamine dihydrochloride on the plasma pepsinogen in dogs was investigated. The animals were studied in acute experiments under sodium pentobarbital (Nembutal) anesthesia. They were protected against the systemic effects of histamine by the antihistaminic drug promethazine HCl (Phenergan). Sodium pentobarbital anesthesia alone or anesthesia and antihistaminic drug together did not result in the rise of plasma pepsinogen. Plasma pepsinogen was increased in the dogs treated with histamine and the degree of elevation of this enzyme varied directly according to the dose of histamine administered.

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