Adjuvant-induced inflammatory disease in the rat: Plasma levels of peptide hydrolases and protease inhibitors reflect disease activity

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Abstract
Both during the primary (localized) inflammation and the development of the secondary (generalized) inflammation in adjuvant-treated rats, the plasma level of functional α-macroglobulins increases while proteases (measured as peptide hydrolases) sharply decrease. The decreased peptide hydrolase levels during episodes when protease ‘spillage’ into the bloodstream is elevated, suggests a more rapid clearance of α-macroglobulin-protease complexes associated with inflammation.

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