Lung Hypoplasia and Surfactant System Immaturity Induced in the Fetal Rat by Prenatal Exposure to Nitrofen
- 1 January 1996
- journal article
- research article
- Published by S. Karger AG in Neonatology
- Vol. 69 (2) , 94-100
- https://doi.org/10.1159/000244283
Abstract
We studied the biochemical maturity of the lungs of fetuses born to rats exposed to nitrofen on day 9.5 of gestation. In comparison with controls, nitrofen-treated fetuses had pulmonary hypoplasia (decreased lung/body weight), lung hypocellularity (low DNA content) and cellular atrophy (low protein/ DNA and phospholipid/DNA) on gestational days 19 and 21. Treated animals with congenital diaphragmatic hernia (CDH) also had cell atrophy and surfactant immaturity (decreased disaturated phosphatidylcholine/DNA) near term. Our data demonstrate that nitrofen causes lung hypoplasia and some degree of surfactant system immaturity that is particularly prominent in fetuses with CDH.Keywords
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