Re-occurrence of HIV-1 drug mutations after treatment re-initiation following interruption in patients with multiple treatment failure
- 1 November 2001
- journal article
- clinical trial
- Published by Wolters Kluwer Health in AIDS
- Vol. 15 (16) , 2189-2191
- https://doi.org/10.1097/00002030-200111090-00016
Abstract
Antiretroviral treatment interruption in 20 extensively pre-treated HIV-1 patients with treatment failure led to genotype viral reversion of at least one class of drug-mutation resistance in half of the patients. The only predictive factor of reversion was found to be the duration of interruption. The outgrowth of residual wild-type virus seems not to be a true genetic reversion because drug mutations are detected rapidly at salvage therapy re-initiation.Keywords
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