Anaphylactic Shock after Retreatment with OKT3 Monoclonal Antibody

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Abstract
The adverse effects that occur in transplant recipients treated with the monoclonal antibody OKT3 include chills, fever, headaches, digestive symptoms, and occasionally pulmonary edema, aseptic meningitis, and even intragraft thromboses.1 , 2 These adverse effects are thought to be caused by cytokines, particularly tumor necrosis factor-α.3 We describe here anaphylactic shock mediated by anti-OKT3 IgE antibodies.