Vault-related resistance to anticancer drugs determined by the expression of the major vault protein LRP
- 1 January 1998
- journal article
- research article
- Published by Springer Nature in Cytotechnology
- Vol. 27 (1/3) , 137-148
- https://doi.org/10.1023/A:1008004502861
Abstract
In this review we analyze the data supporting the notion that vault-related MDR, as reflected by LRP/MVP overexpression, represents a marker of drug resistance in vitro and in the clinic. Vaults, besides playing a fundamental biological role, may be involved in a novel mechanism of MDR.Keywords
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