The GABAA receptor channel mediated chloride ion translocation through the plasma membrane: New insights from 36Cl− ion flux measurements
- 1 January 1993
- Vol. 13 (1) , 74-93
- https://doi.org/10.1002/syn.890130110
Abstract
GABAA receptors in plasma membranes of neurons are integral oligomers which form chloride channels. The binding of GABA molecules at recognition sites for channel opening triggers a transient increase in transmembrane chloride ion flux. The multiplicity and drug specificity of GABAA receptor, kinetics of channel opening, and desensitization of GABAA receptor and its short‐ and long‐term regulation have been investigated by the use of tracer amounts of the radioactive chloride isotope, 36Cl− ion. Results and new insights from 36Cl− ion flux measurements have been reviewed.Keywords
This publication has 108 references indexed in Scilit:
- Mapping of benzodiazepine-like immunoreactivity in the rat brain as revealed by a monoclonal antibody to benzodiazepinesJournal of Chemical Neuroanatomy, 1991
- Regional GABA-stimulated chloride uptake in amygdala kindled ratsNeuroscience Letters, 1991
- Characterization of recombinant GABAA receptors produced in transfected cells from murine α1, β1, and γ2 subunit cDNAsNeuroscience Letters, 1991
- Nerve endings from rat brain tissue release copper upon depolarization. A possible role in regulating neuronal excitabilityNeuroscience Letters, 1989
- Aging reduces the GABA-dependent 36Cl− flux in rat brain membrane vesiclesLife Sciences, 1988
- Action of tremorgenic mycotoxins on GABAA receptorLife Sciences, 1987
- GABA-stimulated 36Cl− influx into reconstituted vesicles with purified GABAA/benzodiazepine receptor complexBiochemical and Biophysical Research Communications, 1987
- γ-Aminobutyric acid (GABA) mediated transmembrane chloride flux with membrane vesicles from rat brain measured by quench flow technique: Kinetic homogeneity of ion flux and receptor desensitizationLife Sciences, 1987
- GABAA receptor-controlled 36Cl− influx in cultured rat cerebellar granule cellsLife Sciences, 1987
- Gamma-aminobutyric acid and alcohol actions: Neurochemical studies of long sleep and short sleep miceLife Sciences, 1986