DNA Content of Micronuclei in Human Lymphocytes

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Abstract
The distribution of DNA contents in micronuclei (MN) induced by ionizing radiation in human lymphocytes was calculated on 2 assumptions: the MN arise from acentric chromosome fragments (ACF), and the ACF result from the random breakage and rejoining of chromosomes. About 80% of MN have a DNA content in the range of 0.5-6% of the G1 nucleus. This group is consistent with the model and shows little dependence on radiation dose over the dose range of 0.5-4 Gy [grays], or on lymphocyte culture time, varying from 48 to 76 h. The MN with DNA content from 6 to 20% of the G1 nucleus are probably the result of both spindle defects and of DNA synthesis in MN.

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