THE ABSORPTION OF TRI-ORTHO-CRESYL PHOSPHATE THROUGH THE SKIN OF HENS AND ITS NEUROTOXIC EFFECTS

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Abstract
Functional and neurohistological studies in 40 chickens painted on the comb with 0.1 ml of tri-ortho-cresyl phosphate (TOCP)/kg or more show a characteristic paralysis of leg extensors and selected spinal tract degeneration of both myelin and axone. Even a single dose of 0.05 ml TOCP/kg is capable of causing a small amount of nerve fiber degeneration in the anterior medial tract of the cord. No degeneration of peripheral nerves of the leg was detected with the dosage used.