Transglutaminases
- 1 January 1984
- journal article
- review article
- Published by Springer Nature in Molecular and Cellular Biochemistry
- Vol. 58 (1-2) , 9-35
- https://doi.org/10.1007/bf00240602
Abstract
This paper is intended as a background to the topic of transglutaminases, while focusing on current ideas regarding the biological roles of these enzymes. Specifically, the following topics are discussed: geometry of forming γ-glutamyl-ε-lysine cross-linked structures; energetic considerations; the γ-glutamyl-ε-lysine cross-link; amine incorporation assays; artefactual incorporation of amines in cells and tissue homogenates; synthetic substrate systems; regulation of transglutaminase activities; strategies for probing transglutaminase-mediated events in biological systems; the blood clotting paradigm; transglutaminase and cell aging: the Ca2+-enriched human erythrocyte; transglutaminase and cell activation: the thrombin-stimulated human platelet and the fertilized sea urchin egg.Keywords
This publication has 116 references indexed in Scilit:
- Inactivation of yeast ornithine decarboxylase by polyamines invivo does not result from the incorporation of polyamines into enzyme proteinBiochemical and Biophysical Research Communications, 1982
- New thioester substrates for fibrinoligase (coagulation factor XIIIa) and for transglutaminase. Transfer of the fluorescently labeled acyl group to amines and alcoholsBiochemistry, 1981
- Posttranslational modification of ornithine decarboxylase by its product putrescineBiochemical and Biophysical Research Communications, 1981
- Inhibitors of 125I-epidermal growth factor internalizationBiochemical and Biophysical Research Communications, 1980
- Differences between Type I Autoimmune Inhibitors of Fibrin Stabilization in Two Patients with Severe Hemorrhagic DisorderJournal of Clinical Investigation, 1978
- Transglutaminase reactions associated with the rat semen clotting system: Modulation by macromolecular polyanionsBiochemical and Biophysical Research Communications, 1977
- Dissociation of the subunit structure of fibrin stabilizing factor during activation of the zymogenBiochemical and Biophysical Research Communications, 1974
- Titration and subunit localization of active center cysteine in fibrinoligase (thrombin-activated fibrin stabilizing factor)Biochemical and Biophysical Research Communications, 1973
- Haemorrhagic Syndrome of Autoimmune Origin with a Specific Inhibitor against Fibrin Stabilizing Factor (Factor XIII)*British Journal of Haematology, 1972
- The transpeptidase system which crosslinks fibrin by γ-glutamyl-ε-lysine bondsBiochemical and Biophysical Research Communications, 1968