Efficient Synthesis of Enantiopure Tretrahydroisoquinolines by Diastereoselective Intramolecular Heck Reaction Using α-Amino Acid Derivatives
- 1 January 1994
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1994 (12) , 1331-1336
- https://doi.org/10.1055/s-1994-25690
Abstract
A new facile method for the synthesis of enantiopure 3,4-disubstituted tetrahydroisoquinolines 10a-d and 14 is described. Starting from commercially available α-amino acids the compounds 3a-d and 4 were prepared by an easy five-step sequence and afterwards cyclized selectively in an intramolecular Heck reaction using Pd(OAc)2, PPh3, TPAB and KOAc.Keywords
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