Immunoregulation in Autoimmune Thyroid Disease

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Abstract
Times change. This trite but apt phrase can safely be applied to the study of autoimmune thyroid diseases, including Graves' disease and Hashimoto's thyroiditis and its variants, to reflect the remarkable progress made during the past three decades. This period began in 1956 with the seminal discoveries of thyroid antibodies by Roitt and Doniach, of experimental autoimmune thyroiditis by Rose and Witebsky, and of an abnormal thyroid stimulator in Graves' disease by Adams and Purves.1 In 1972 I contributed an editorial to the Journal 2 in which I indicated that cell-mediated immunity had then been demonstrated in Graves' disease and further . . .