Intradermal Desensitization with Human Insulin (recombinant DNA) in a Patient with Severe Allergic Skin Reaction due to Insulin
- 1 November 1982
- journal article
- case report
- Published by American Diabetes Association in Diabetes Care
- Vol. 5 (Supplement) , 165-167
- https://doi.org/10.2337/diacare.5.2.s165
Abstract
This is a case report of a 70-yr-old female patient with a severe allergic skin reaction (necroses) due to insulin injections. Because of insulin dependency, desensitization to insulin was mandatory. For desensitization, a schedule with intradermal injections of increasing insulin concentrations (from 0.02 to 2 U per injection) at time intervals of 3 h was used. With highly purified pork insulin, the concentration limit of 0.04 U was reached in spite of 75 injections. After changing to human insulin (recombinant DNA), a rapid desensitization could be performed at the same concentration. Desensitization resulted not only to human insulin but also to highly purified pork insulin, as shown by intradermal testing 6 mo later.Keywords
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