Organization of 5′proximalc-mybexons in chicken DNA Implications forc-mybtissue-specific transcription

9 May 1988

journal article
Published by Wiley in FEBS Letters

Vol. 232 (1) , 227-234
https://doi.org/10.1016/0014-5793(88)80422-8

Abstract

The organization of 5′-proximal c-myb exons in chicken DNA has been established by restriction enzyme mapping and nucleotide sequencing. Hybridization studies performed with cDNA probes revealed that yolk sac and thymic c-myb RNAs differ in their 5′-termini. A comparison of the genomic c-myb sequence with that of cDNAs isolated from normal thymic and lymphoma avian cells suggests that different promoter regions are used to initiate c-myb transcription in hematopoietic cells of different origins.

Keywords

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