Massive Crooke's hyalinization in corticotroph cell adenomas of the human pituitary
- 1 September 1981
- journal article
- research article
- Published by Springer Nature in Acta Neurochirurgica
- Vol. 58 (3-4) , 235-243
- https://doi.org/10.1007/bf01407130
Abstract
Three women with Cushing's disease caused by ACTH-producing adenoma, underwent transsphenoidal tumour resection. Many adenoma cells showed massive accumulation of microfilaments indistinguishable from Crooke's hyaline material by light and electron microscopy. We believe that these tumours represent variants of ACTH-producing adenomas, and the accumulation of microfilaments is due to cortisol dependency.This publication has 23 references indexed in Scilit:
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