Genetic Regulation of Metabolic Pathways in β-Cells Disrupted by Hyperglycemia
Open Access
- 1 March 2002
- journal article
- Published by Elsevier in Journal of Biological Chemistry
- Vol. 277 (13) , 10912-10921
- https://doi.org/10.1074/jbc.m111751200
Abstract
No abstract availableKeywords
This publication has 52 references indexed in Scilit:
- Uncoupling Protein-2 Negatively Regulates Insulin Secretion and Is a Major Link between Obesity, β Cell Dysfunction, and Type 2 DiabetesCell, 2001
- Uncoupling Protein-2 Participates in Cellular Defense against Oxidative Stress in Clonal β-CellsBiochemical and Biophysical Research Communications, 2001
- Prostaglandin E2 Mediates Inhibition of Insulin Secretion by Interleukin-1βJournal of Biological Chemistry, 1999
- Induction of Uncoupling Protein-2 mRNA by Troglitazone in the Pancreatic Islets of Zucker Diabetic Fatty RatsBiochemical and Biophysical Research Communications, 1997
- Glucose promotes survival of rat pancreatic beta cells by activating synthesis of proteins which suppress a constitutive apoptotic program.Journal of Clinical Investigation, 1996
- Interleukin-1 Enhances Pancreatic Islet Arachidonic Acid 12-Lipoxygenase Product Generation by Increasing Substrate Availability through a Nitric Oxide-dependent MechanismPublished by Elsevier ,1996
- Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle.Journal of Clinical Investigation, 1994
- β-Cell Dysfunction Induced by Chronic Hyperglycemia: Current Ideas on Mechanism of Impaired Glucose-Induced Insulin SecretionDiabetes Care, 1992
- Partial pancreatectomy in the rat and subsequent defect in glucose-induced insulin release.Journal of Clinical Investigation, 1983
- Increase in insulin response after treatment of overt maturity-onset diabetes is independent of the mode of treatmentDiabetologia, 1980