Pantothenic Acid Deficiency and Reproduction in the Rat

Abstract
Reproduction has been studied in normal adult female rats placed on purified diets deficient in pantothenic acid before or during the gestation period. Pantothenic acid deficiency instituted on the thirteenth day of gestation did not interfere with the reproductive function. Pantothenic acid deficiency instituted 16–23 days before mating or as late as the day of mating always resulted in failure of implantation, resorption, or defective litters. The normality of reproduction in pantothenic acid-fed controls restricted in calories eliminated the factors of inanition and of other specific dietary deficiencies as causes for these marked upsets in reproduction.

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