Functions of Prefrontal Cortex in Animals

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Abstract
Analysis of behavioral changes in monkeys with frontal lesions reveals that the prefrontal cortex is essential for important inhibitory capacities. Ablation of prefrontal cortex is associated with removal of inhibition and with regression to primitive forms of motor and motivational behavior patterns. Loss of inhibition of competing response tendencies (response preservation) and impairment of inhibition referred to as "drive disinhibition" may reflect the relation of the prefrontal cortex to llmbic-subcortical structures via the caudate-subthalamic-hippocampal complex and the hypothalamic-amygdaloid complex, respectively.