Current contributions of peptide synthesis to studies on brain‐gut‐skin triangle peptides
- 1 October 1985
- journal article
- review article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 26 (4) , 337-361
- https://doi.org/10.1111/j.1399-3011.1985.tb01001.x
Abstract
The usefulness of a strong acid, such as MSA or TFMSA/TFA, as a deprotecting reagent in peptide synthesis was examined. By synthesizing several structurally related brain-gut-skin triangle peptides, a number of advantageous features of the thioanisole-mediated deprotecting procedure were demonstrated. New amino acid derivatives, Arg(Mts), Trp(Mts) and Asp(OChp), were introduced to improve the synthetic methodology of complex peptides and the superior properties of Cys(Ad) were evaluated.Keywords
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