Doxapram Hydrochloride as a Respiratory Stimulant in Anesthetized Man

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Abstract
Brief respiratory stimulant and arousal effects of doxapram hydrochloride given at 0.5 or 1.0 mg/kg were demonstrated in 7 subjects under thiopental anesthesia. The most marked effect was an increase in tidal and minute volume with a rise in arterial P02. a fall in PCO2, and a rise in pH at both dose levels. There was a significant increase in heart rate at 1.0 mg/kg only, and no changes in eeg, ecg or blood pressure with either dose. In the doses studied doxapram hydrochloride appears to be a transient potent respiratory stimulant in anesthetized human subjects. Further work remains to be done concerning the efficacy and mode of action under various depressant circumstances.

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