Evidence for Mutation to Streptomycin Resistance in Clinical Strains of Staphylococcus aureus

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Abstract
SUMMARY In three clinical strains of Staphylococcus aureus and one laboratory mutant (609 str-r) the gene determining streptomycin resistance was probably at a single chromosomal locus. Cell-free systems from these, and an additional clinical strain, showed little inhibition of protein synthesis in the presence of streptomycin, whereas systems from sensitive staphylococci were markedly affected by strepto- mycin.