The 158V polymorphism of Fc gamma receptor type IIIA in early rheumatoid arthritis: increased susceptibility and severity in male patients (the Swedish TIRA**TIRA is a Swedish acronym for ‘early invention in rheumatoid arthritis’ and is a multicentre cooperation between rheumatology units in southeastern Sweden. project)

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Abstract
Objectives. To evaluate the influence of Fcγ receptor IIIA (FcγRIIIA) 158V/F polymorphism on susceptibility and disease severity in early rheumatoid arthritis (RA). Methods. In 181 Swedish patients (128 women, 53 men) with RA of recent onset, disease and disability variables such as erythrocyte sedimentation rate, 28-joint disease activity score (DAS28) and health assessment questionnaire (HAQ) scores were monitored regularly during 3 yr. Three hundred and sixty-two controls were recruited from the same geographical area as the patients. FcγRIIIA genotyping was performed using denaturing high-performance liquid chromatography. Results. In all RA patients, FcγRIIIA-158VV was significantly over-represented compared with controls [odds ratio (OR) 1.9, 95% confidence interval (CI) 1.01–3.5, PPP=0.4). In addition, 158VV patients were more likely to exhibit early joint erosions (OR 6.1, 95%CI 1.4–28, PConclusions. In a male population, the FcγRIIIA-158VV genotype is associated with an increased risk of developing RA, and the 158V allele with more severe disease in early RA.