I.V. LABETALOL IN THE TREATMENT OF HYPERTENSION FOLLOWING CORONARY-ARTERY SURGERY

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Abstract
The cardiovascular effects of incremental fixed i.v. doses of labetalol were evaluated in 10 normovolaemic sedated patients presenting with hypertension and tachycardia in the early period after myocardial revas-cularizaoon. A first dose of 20 mg was sufficient to provoke a (P < 0.01) mean decrease in systolic (−9.3%), diastolic (−8.2%) and mean arterial (−7.9%) pressure (AP) and in the rate-pressure product (RPP) (−13.1%). The mean heart rate (HR) did not change significantly, but a linear correlation could be established between the change at 2 min and the value before injection (r = 0.73). A second dose of labetalol 40 mg given S min later did not decrease AP further, but a significant decrease in HR was noted. A marked difference in the individual response among patients was found as the range of effective total doses per kg body weight was 0.6–4.1 mg kg−1 (mean 2.2). Apart from one patient, no patient needed vagolytic or sympathomimetic drugs to oppose the alpha or beta actions of labetalol during the 24-h follow-up period.