The Effect of Uremia on the Pyrogenic Response of Rabbits

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Abstract
In order to determine the effect of uremia on the febrile response to pyrogen-ic stimuli, normal rabbits and animals made uremic with cephaloridine were challenged with endotoxin and leukocyte pyrogen and their febrile response was recorded. In addition, the ability of granulocytes from untreated and uremic antimals to elaborate leukocyte pyrogen in vitro was evaluated. No difference was observed in the febrile response of normal or uremic animals to these pyrogens nor was any impairment noted in the ability of granulocytes from uremic animals to generate leukocyte pyrogen. A correlation between high levels of blood urea nitrogen, low values of serum calcium, and a lowered basal body temperature was found.

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