Effect of cholecystectomy on mouth-to-cecum transit of a liquid meal

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Abstract
Mouth-to-cecum transit and serum bile acid profile after ingestion of a lactulose-labeled liquid meal (440 kcal) were measured in eight patients with gallstones and a radiologically functioning gallbladder before and three to five months after cholecystectomy and in 15 controls. In the patients mouth-to-cecum transit was longer after the operation, 87.5±18.5 (mean±sem)min vs 57.5±9.7 min (PP = NS) in patients and controls, while total bile acid and cholylglycine fasting concentrations were higher after cholecystectomy (PP<0.01 respectively). Cholecystectomy prolongs mouth-to-cecum transit of a liquid meal.