Pancreatic Transplantation Experience in 121 Cases

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Abstract
From October 1976 to November 1988, 121 pancreatic transplantation (TX) were performed in 114 insulin-dependent diabetes patients (IDD; 71 males and 43 females, mean age 37 years, mean duration of IDD 23 years). 101 transplantations were simultaneous kidney and pancreas TX, 13 were pancreas TX alone, and 7 were nonsimultaneous double TX. Surgical techniques used were duct obstruction by neoprene injection of segmental grafts in 107 patients and 14 pancreaticoduodenal transplantations with enteric drainage. Actuarial survival of kidney and pancreas was, respectively, 77 and 48% at 1 year and 67 and 40% at 2 years. Results gradually improved with new immunosuppression using quadruple therapy. Losses of pancreatic grafts were due to rejection (27 cases), thrombosis (24 cases), pancreatitis (3 cases), and death with a functional graft (18 cases). In November 1988, 43 patients have functional grafts and are off insulin. Amelioration of neuropathy was observed in most patients; however, this may be due to normalization of renal function.

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