Potentiation of hypoxic pulmonary vasoconstriction by ethyl alcohol in dogs

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Abstract
Pulmonary and systemic hemodynamics and arterial blood gases were measured in anesthetized and mechanically ventilated dogs before and after oral or i.v. administration of ethanol. Increases in mean pulmonary artery pressure and pulmonary vascular resistance occurred. Platelet antiserum-induced thrombocytopenia inhibition of prostaglandin synthesis and meclofenamate or .alpha.-adrenergic blockade did not alter the pulmonary pressor response to ethanol. The increase in resistance following ethanol was abolished by hyperoxia and potentiated by hypoxia. The effect of ethanol is apparently to augment hypoxic pulmonary vasoconstriction; ethanol per se has no independent pulmonary pressor activity.

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