Column Asymmetric Catalysis for β-Lactam Synthesis
- 16 November 2000
- journal article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 2 (25) , 3963-3965
- https://doi.org/10.1021/ol006659r
Abstract
A catalytic asymmetric reaction process was designed involving the use of solid-phase reagents and catalysts that constitute the packing of a series of “reaction columns”. This process was applied to the catalytic asymmetric synthesis of β-lactams, yielding pure product after crystallization with exceptional enantio- and diastereoselectivity.Keywords
This publication has 7 references indexed in Scilit:
- Catalytic, Asymmetric Synthesis of β-LactamsJournal of the American Chemical Society, 2000
- Solid‐Phase Synthesis and Combinatorial TechnologiesPublished by Wiley ,2000
- Polymer-Supported Chiral Co(Salen) Complexes: Synthetic Applications and Mechanistic Investigations in the Hydrolytic Kinetic Resolution of Terminal EpoxidesJournal of the American Chemical Society, 1999
- Polymer supports for solid-phase organic synthesisBiopolymers, 1998
- Chemical Library Purification Strategies Based on Principles of Complementary Molecular Reactivity and Molecular RecognitionJournal of the American Chemical Society, 1997
- Asymmetric Diels−Alder Reaction of Methacrolein with Cyclopentadiene Using Polymer-Supported Catalysts: Design of Highly Enantioselective Polymeric CatalystsThe Journal of Organic Chemistry, 1996
- Novel, Very Strong, Uncharged Auxiliary Bases; Design and Synthesis of Monomeric and Polymer‐Bound Triaminoiminophosphorane Bases of Broadly Varied Steric DemandEuropean Journal of Inorganic Chemistry, 1994