Domino Hydroformylation-Wittig Reactions

journal article
Published by Wiley in Angewandte Chemie International Edition in English

Vol. 38 (7) , 969-971
https://doi.org/10.1002/(sici)1521-3773(19990401)38:7<969::aid-anie969>3.0.co;2-4

Abstract

Methallyl and homomethallyl alcohols can undergo stereoselective hydroformylation-Wittig and hydroformylation-Wittig-hydrogenation reactions in one-pot domino processes. This sequential transformation allows the formation of C-C bonds and the generation of a new stereogenic center, and gives preparatively interesting compounds [Eq. (a)]. The reaction products are obtained in satisfactory to good yields and in diastereoselectivities of 90:10 to >98:2. CDG=catalyst-directing group; R'=H; R″=OEt, Me.

Keywords

ASYMMETRIC SYNTHESIS
DOMINO REACTIONS
HYDROFORMYLATIONS
SYNTHETIC METHODS
WITTIG REACTIONS

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