Adaptive β-Cell Proliferation Is Severely Restricted With Advanced Age
Top Cited Papers
Open Access
- 5 March 2009
- journal article
- Published by American Diabetes Association in Diabetes
- Vol. 58 (6) , 1365-1372
- https://doi.org/10.2337/db08-1198
Abstract
OBJECTIVE Regeneration of the insulin-secreting β-cells is a fundamental research goal that could benefit patients with either type 1 or type 2 diabetes. β-Cell proliferation can be acutely stimulated by a variety of stimuli in young rodents. However, it is unknown whether this adaptive β-cell regeneration capacity is retained into old age.Keywords
This publication has 43 references indexed in Scilit:
- Partial Pancreatectomy in Adult Humans Does Not Provoke β-Cell RegenerationDiabetes, 2008
- Measurement of pancreatic islet cell proliferation by heavy water labelingAmerican Journal of Physiology-Endocrinology and Metabolism, 2007
- Recovery from diabetes in mice by β cell regenerationJournal of Clinical Investigation, 2007
- A Genome-Wide Association Study of Type 2 Diabetes in Finns Detects Multiple Susceptibility VariantsScience, 2007
- All β Cells Contribute Equally to Islet Growth and MaintenancePLoS Biology, 2007
- Preexisting pancreatic acinar cells contribute to acinar cell, but not islet β cell, regenerationJournal of Clinical Investigation, 2007
- Molecular regulation of pancreatic β-cell mass development, maintenance, and expansionJournal of Molecular Endocrinology, 2007
- Intrinsic Regulators of Pancreatic β-Cell ProliferationAnnual Review of Cell and Developmental Biology, 2006
- p16INK4a induces an age-dependent decline in islet regenerative potentialNature, 2006
- Glucagon-like Peptide-1 Receptor Signaling Modulates β Cell ApoptosisJournal of Biological Chemistry, 2003