THE EFFECT OF FLUID DEPRIVATION AND FLUID INTAKE UPON THE REVIVAL OF DOGS FROM ADRENAL INSUFFICIENCY

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Abstract
Eight adrenalectomized dogs, exhibiting severe symptoms and deprived of food and water for periods of 24-72 hrs. while receiving injections of cortical hormone, were capable of mobilizing sufficient fluid (and salt presumably) in the tissues and interstitial spaces for transfer to the blood stream to permit revival to the point where to all appearances, activities, appetite, etc., the dogs seemed normal. However, considerable fluid intake was required for complete restoration of blood pressure, Hb and urea N to normal levels. The adrenalectomized dog, in the absence of the cortical hormone, is apparently unable to mobilize the fluids of its tissues and interstitial tissue spaces for use in maintaining a normal volume of circulating fluid. Hypo-glycemia could not be regarded as an important factor in these exps, since significant alterations of the blood glucose were not observed in this series of experimental animals, even when they exhibited severe symptoms.

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