Progesterone Therapy and Progestin Metabolism in Abortion1

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Abstract
The results of therapy for the prevention of abortion, progesterone being the common therapeutic element, are reported in 54 patients. 16 of these patients had histories of recurrent abortion; pregnancy was maintained in 50%. Thirty had histories of threatening abortion; pregnancy was maintained in 57%. 8 had pre-gestational diagnoses of ovarian failure; pregnancy was maintained in 75% of these. Thyroid substance was an important adjunct, if not the major therapeutic factor, in patients with hypometabolism. The earlier that prophylactic therapy is started and the later the appearance of symptoms which necessitate active therapy, the better the results of therapy. Oral anhydro-hydroxyprogesterone was apparently as efficient as injected progesterone. The Na pregnanediol glucuronide excretion values of 14 patients were studied. Six of 7 patients who excreted normal levels of pregnanediol went to term. Four patients who had initially and continually low levels aborted or miscarried. 3 patients who had normal levels followed by zero or near zero values aborted or miscarried within a few days after the sudden drop in the pregnanediol excreted.

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