A cyclodextrin to reverse the regioselectivity of nitrile oxide cycloaddition to a terminal alkene
- 1 January 1997
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 16,p. 1517-1518
- https://doi.org/10.1039/a703575f
Abstract
The 1,3-dipolar cycloaddition of 4-tert-butylbenzonitrile oxide with 6 A -acrylamido-6 A -deoxy-β-cyclodextrin in aqueous solution favours formation of the 4-substituted isoxazoline, in contrast to the normal predominance of the 5-substituted regioisomer from reactions of monosubstituted alkenes.Keywords
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