THE ELABORATION OF HISTAMINE IN VIVO

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Abstract
Recently we repeated the work of Katz,1who reported the intravenous administration of diethyl ether for the treatment of impending ischemic gangrene and other peripheral vascular disorders. Twelve consecutive unselected cases of definite peripheral vascular disease were treated by this method. According to the usual criteria there was improvement in 5. In 7 patients pain was not relieved throughout the twenty-four hour period, and in 8 certain unfavorable reactions were noted (table 1). Dale and Laidlaw2found that ether sensitized the capillaries to the action of histamine, so that but one tenth of the dose needed in unanesthetized cats was necessary to produce "histamine shock." Histamine is known to increase the acid secretion of the gastric juice, the blood plasma receiving the resulting alkaline factors,this leading to the so-called urinary alkaline tide. In man, histamine produces dilatation of the arterioles, venules and capillaries. Drinker3states

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