INTESTINAL ABSORPTIVE CAPACITY AND SITE OF ABSORPTION OF FAT UNDER STEADY STATE CONDITIONS IN THE UNANÆSTHETIZED RAT

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Abstract
The maximum intestinal absorptive capacity for tricaprylin (C8) was established, and found to be approximately four times that for coconut oil (70 per cent C12 fatty acids). Infusion of fats of varying chain length into gut remaining after resection of most of the jejunum or most of the ileum revealed little difference in proximal and distal absorptions. In addition, the maximum absorptive capacity for tricaprylin was not significantly reduced by removal of 40 per cent of the small intestine, either jejunum or ileum. The results suggest that rapid propulsion through the proximal intestine prevents proximal absorption under normal conditions, but that true regional specificity for fat absorption does not exist in rats.

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