The Effect of Anaesthetics on the Electrocorticogram of the Intrauterine Guinea Pig Foetus

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Abstract
Electrocorticograms were recorded from intrauterine guinea pig fetuses duringmaternalanaesthesia. Light ether or barbiturate anaesthesia generally exerted no more than a slight effect upon the fetal electrocorticogram, whereas deep anaesthesia depressed it markedly. Nitrous oxide (80%) did not affect the fetal electrocorticogram to a significant extent. No significant age differences were observed. Repetitive doses of anaesthetics markedly impair the restitution of the fetal electrocorticogram, especially where barbiturates are concerned. For obstetrical use, nitrous oxide seems the least disadvantageous to the fetus, whereas the cmulative action of even short acting barbiturates Imposes limitations on their use.

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