Recurrent Pulmonary Infiltration and Pleural Effusion Due to Nitrofurantoin Sensitivity

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Abstract
PULMONARY disease with eosinophilia, either transient or chronic, has been observed in patients with and without asthma, often as the result of drug allergy or of parasites.A patient recently encountered is of interest because of several features: there was no history of prior allergic reactions, the lesions recurred in the same pulmonary segments over a five-week period, the clinical and radiologic changes simulated pulmonary embolism, marked eosinophilia was not manifested until the third episode and the cause of the recurrent pneumonias was shown to be nitrofurantoin.‡ Severe reactions to this drug have been reported,1 but it has not previously . . .