Rapidly Progressive Pulmonary Alveolar Proteinosis in a Patient with Chronic Myelogenous Leukemia.
- 1 January 1994
- journal article
- case report
- Published by Japanese Society of Internal Medicine in Internal Medicine
- Vol. 33 (11) , 710-713
- https://doi.org/10.2169/internalmedicine.33.710
Abstract
A 46-year-old man with chronic myelogenous leukemia (CML) was admitted to our hospital because of high fever. The chest radiographs showed bilateral groundglass-like infiltrates in the perihilar region. Transbronchial lung biopsy (TBLB) and autopsy revealed PAS-positive granular materials characteristic of pulmonary alveolar proteinosis (PAP). He had received interferon-alpha since the time of CML diagnosis. Busulfan had never been administered. Altered cell-mediated immunity was thought to be closely related to the development of PAP.Keywords
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