Abstract
Following double suprarenalectomy in dogs the blood became quite concentrated, as indicated by increase in total N, total solids, and ratio of corpuscles to plasma. Accompanying these, particularly as a terminal stage phenomenon, was an increase in urea and non-protein N. Variations in Ca and P were not marked and were about what would be expected due to the concentration of the blood and changes in food. As the intoxication resembled his-tamine shock, the livers of some of these dogs were analyzed for histamine; although a normal constituent of the liver, there was some increase in the amounts present. Changes in blood cholesterol were slight and the ratio of free to ester was practically unchanged. Urinary analyses indicated that the kidneys were able to excrete nitrogenous and inorganic waste until the last stage before death.

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