Anti-acetylcholine receptor antibodies directed against the alpha-bungarotoxin binding site induce a unique form of experimental myasthenia.
- 1 July 1983
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 80 (13) , 4089-4093
- https://doi.org/10.1073/pnas.80.13.4089
Abstract
Of 7 rat monoclonal antibodies directed against nicotinic acetylcholine receptor, the 3 whose binding was blocked by .alpha.-bungarotoxin produced acute paralysis in chicken hatchlings, whereas the 4 others had no effect. In the effected animals, weakness and decremental EMG responses appeared within 1 h after i.v. injection and both abnormalities improved after anticholinesterase administration. No histologic changes were seen in the muscle of injected animals. Antibodies binding in relationship to the cholinergic binding site, and presumably producing pharmacologic blockade of acetylcholine receptor, may play an important role in the pathogenesis of the defective neuromuscular transmission in myasthenia gravis.This publication has 34 references indexed in Scilit:
- Myasthenia induced by monoclonal anti‐acetylcholine receptor antibodies: Clinical and electrophysiological aspectsAnnals of Neurology, 1981
- Autoimmune Response to Acetylcholine Receptors in Myasthenia Gravis and Its Animal ModelPublished by Elsevier ,1979
- Acetylcholine Receptor Antibody in Myasthenia Gravis: Purification and CharacterizationScandinavian Journal of Immunology, 1978
- Modulation of acetylcholine receptor in rat diaphragm by anti-receptor seraNature, 1978
- Human myasthenic sera reduce acetylcholine sensitivity of human muscle cells in tissue cultureNature, 1977
- Myasthenic Immunoglobulin Accelerates Acetylcholine Receptor DegradationScience, 1977
- Characterization of Torpedo californica Acetylcholine Receptor: Its Subunit Composition and Ligand-binding PropertiesCold Spring Harbor Symposia on Quantitative Biology, 1976
- Experimental autoimmune myasthenia: A model of myasthenia gravis in rats and guinea pigs.The Journal of Experimental Medicine, 1975
- Neuromuscular Junction in Myasthenia Gravis: Decreased Acetylcholine ReceptorsScience, 1973
- Search for a neuromuscular blocking agent in the blood of patients with myasthenia gravisThe American Journal of Medicine, 1959