Malignant Melanoma

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Abstract
PIGMENT cells, normal and abnormal, have been A the subject of much recent biologic and chemical study.1,2 This report summarizes such data, and in addition presents the current understanding of the genesis, diagnosis and therapy of the malignant melanoma.MelanocytesMelanin production occurs only in cells, normal or neoplastic, possessing the enzyme tyrosinase that catalyzes the reaction: tyrosine → melanin. Tyrosinase-containing cells have been demonstrated principally in the epidermis, eye and meninges; these areas are the most frequent locations of the malignant melanoma. Numerous explanations have been offered for the occurrence of melanin outside such sites, including the extracellular escape . . .
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