Comparison of 133Xe Washout Curves after Bolus Inhalation, Perfusion, and Equilibration

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Abstract
In 6 healthy subjects and 13 patients with chronic obstructive lung disease, 133Xe washout curves after bolus inhalation, perfusion and equilibration were compared, using a .gamma. camera and computerized data handling. In healthy subjects the washout after equibration was significantly slower than after the 2 other procedures. As this phenomenon occurred at the basal zones, it was attributed to the presence of airway closure in some units. In patients the 3 washouts were significantly different from each other. This indicated the existence of intraregional inhomogeneity in ventilation, perfusion and ventilation-perfusion ratio. Comparison of these different washout methods yields valuable information not only on absolute values of pulmonary function, but also on the intraregional distribution, which cannot be obtained by other examinations.

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