Phosphorylation of Troponin I by Protein Kinase A Accelerates Relaxation and Crossbridge Cycle Kinetics in Mouse Ventricular Muscle
- 25 May 2001
- journal article
- other
- Published by Wolters Kluwer Health in Circulation Research
- Vol. 88 (10) , 1059-1065
- https://doi.org/10.1161/hh1001.091640
Abstract
—Phosphorylation of cardiac myofibrils by cAMP-dependent protein kinase (PKA) can increase the intrinsic rate of myofibrillar relaxation, which may contribute to the shortening of the cardi...Keywords
This publication has 21 references indexed in Scilit:
- A role for C‐protein in the regulation of contraction and intracellular Ca2+ in intact rat ventricular myocytesThe Journal of Physiology, 2000
- Attenuation of length dependence of calcium activation in myofilaments of transgenic mouse hearts expressing slow skeletal troponin IThe Journal of Physiology, 2000
- Impaired cardiomyocyte relaxation and diastolic function in transgenic mice expressing slow skeletal troponin I in the heartThe Journal of Physiology, 1999
- Protein Kinase A Increases the Tension Cost and Unloaded Shortening Velocity in Skinned Rat Cardiac MuscleJournal of Molecular and Cellular Cardiology, 1997
- Alteration of myosin cross bridges by phosphorylation of myosin-binding protein C in cardiac muscle.Proceedings of the National Academy of Sciences, 1996
- The Unique Amino-terminal Peptide of Cardiac Troponin I Regulates Myofibrillar Activity Only When it is PhosphorylatedJournal of Molecular and Cellular Cardiology, 1995
- Adrenaline increases the rate of cross-bridge cycling in rat cardiac muscleJournal of Molecular and Cellular Cardiology, 1990
- Biologically useful chelators that take up calcium(2+) upon illuminationJournal of the American Chemical Society, 1989
- Effect of isoproterenol on force transient time course and on stiffness spectra in rabbit papillary muscle in barium contractureJournal of Molecular and Cellular Cardiology, 1988
- Phosphorylation of the inhibitory subunit of troponin and its effect on the calcium dependence of cardiac myofibril adenosine triphosphataseFEBS Letters, 1976