QUALITATIVE STUDY ON THE KUPFFER CELLS IN THE LIVER OF ETHANOL‐ AND CARBON TETRACHLORIDE‐TREATED RATS

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Abstract
The treatment of rats with ethanol or CCl4 caused, in addition to an increase in numbers, qualitative changes in the Kupffer cells. The rate of phagocytosis of opsonized [sheep] erythrocytes was greatly increased in the Kupffer cells from CCl4-treated rats, compared with a slightly decreased phagocytosis in similar cells taken from ethanol-treated rats. The number of Fc-receptors per cell was slightly higher in the Kuppffer cells from ethanol- and CCl4-treated rats than in normal rats. Although the nonparenchymal cell fraction from the livers of ethanol- and CCl4-treated rats contained more mononuclear phagocytes than the respective control samples, both the adhering and nonadhering subfractions from the livers of ethanol-treated rats contained proportionally fewer mononuclear phagocytes following an asssessment of adhesiveness than the other samples. No difference in esterase staining was observed between the groups.