The ichthyotoxicity and coronary vasodilator action of 3,3'-dihydroxy-.ALPHA.,.BETA.-diethylstilbene.
- 1 January 1987
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 35 (2) , 887-890
- https://doi.org/10.1248/cpb.35.887
Abstract
Like diethylstilbestrol (II), 3,3''-dihydroxy-.alpha.,.beta.-diethyl-stilbene (I), an isomer of II, had strong ichthyotoxicity and coronary vasodilator action on the isolated guinea-pig heart. The median tolerance limit (TLm) at 48 h was 3.00 ppm in Oryzias latipes and 3.20 ppm in Carassius auratus. The ichthyotoxic activity of I was stronger than that of II. The vasodilator activity of I in the isolated guinea-pig heart (ED50:4.30 .mu.g/heart) was weaker than that of II (ED50: 0.26 .mu.g/heart). However, the action of I was stronger than that of papaverine (ED50: 7.0 .mu.g/heart), used as a standard. On the other hand, I, unlike II and other oxystilbene derivatives so far examined, had a cardiotonic effect. In this respect, the effect of I on the isolated guinea-pig heart is noteworthy. Owing to its negligible hormonal side effect, the above-mentioned activities of I. are of considerable interest.This publication has 1 reference indexed in Scilit:
- The biological activities of diethylstilbestrol and its derivatives.CHEMICAL & PHARMACEUTICAL BULLETIN, 1985